| 1. Round | 02/07/2022 | Deportivo Guadalajara [U20] | - | FC Juárez [U20] | 3:1 | ||||
| 3. Round | 05/07/2022 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 2. Round | 09/07/2022 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 3:1 |  |
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| 4. Round | 20/07/2022 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:3 | ||||
| 5. Round | 27/07/2022 | Gallos Blancos [U20] | - | Deportivo Guadalajara [U20] | 2:2 | ||||
| 6. Round | 30/07/2022 | Deportivo Guadalajara [U20] | - | CF Pachuca [U20] | 2:2 | ||||
| 7. Round | 05/08/2022 | Mazatlán FC [U20] | - | Deportivo Guadalajara [U20] | 2:1 | ||||
| 8. Round | 13/08/2022 | Deportivo Guadalajara [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 10. Round | 19/08/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:1 |
Mexico