| 1. Round | 07/01/2023 | CF Monterrey [U20] | - | Deportivo Guadalajara [U20] | 1:2 |  |
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| 2. Round | 13/01/2023 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 0:1 |  |
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| 3. Round | 21/01/2023 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 2:1 | ||||
| 4. Round | 28/01/2023 | FC Juárez [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 5. Round | 05/02/2023 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 3:2 | |
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| 6. Round | 11/02/2023 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 7. Round | 15/02/2023 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | |
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| 8. Round | 18/02/2023 | Pumas UNAM [U20] | - | Deportivo Guadalajara [U20] | 2:3 | ||||
| 9. Round | 25/02/2023 | UANL Tigres [U20] | - | Deportivo Guadalajara [U20] | 2:0 | ||||
| 11. Round | 10/03/2023 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:0 | ||||
| 12. Round | 18/03/2023 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | |
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| 13. Round | 01/04/2023 | Atlas Guadalajara [U20] | - | Deportivo Guadalajara [U20] | 2:3 | ||||
| 15. Round | 15/04/2023 | Club León [U20] | - | Deportivo Guadalajara [U20] | 2:2 | |
Mexico