| 1. Round | 25/07/2018 | Atlético Huila | - | Independiente Medellín | 0:0 | ||||
| 3. Round | 05/08/2018 | Millonarios | - | Independiente Medellín | 0:1 |  |
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| 4. Round | 12/08/2018 | Deportivo Cali | - | Independiente Medellín | 3:2 | ||||
| 5. Round | 19/08/2018 | Independiente Medellín | - | Águilas Doradas | 1:0 | ||||
| 6. Round | 26/08/2018 | Atlético Junior | - | Independiente Medellín | 2:1 | ||||
| 7. Round | 02/09/2018 | Independiente Medellín | - | Once Caldas | 2:2 | |
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| 8. Round | 07/09/2018 | La Equidad | - | Independiente Medellín | 1:1 | |
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| 9. Round | 09/09/2018 | Independiente Medellín | - | Leones FC | 1:1 | |
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| 10. Round | 16/09/2018 | Deportes Tolima | - | Independiente Medellín | 3:0 | ||||
| 12. Round | 29/09/2018 | Patriotas FC | - | Independiente Medellín | 0:3 | ||||
| 13. Round | 06/10/2018 | Independiente Medellín | - | Atlético Nacional | 2:1 | ||||
| 16. Round | 20/10/2018 | Jaguares de Córdoba | - | Independiente Medellín | 0:2 | ||||
| 18. Round | 05/11/2018 | Deportivo Pasto | - | Independiente Medellín | 1:1 | |
Ecuador