| 6. Round | 24/09/2022 | Inter de Querétaro | - | Colima FC | 1:3 | ||||
| 7. Round | 29/09/2022 | Colima FC | - | Correcaminos UAT II | 4:2 | ||||
| 8. Round | 02/10/2022 | Gavilanes de Matamoros | - | Colima FC | 1:0 | ||||
| 9. Round | 09/10/2022 | Lobos ULMX | - | Colima FC | 3:2 | ||||
| 10. Round | 15/10/2022 | Colima FC | - | Aguacateros CDU | 3:1 |  |
Mexico