| 1. Round | 03/07/2022 | Pumas UNAM [U18] | - | Club Tijuana [U18] | 1:0 |  |
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| 2. Round | 08/07/2022 | Club Tijuana [U18] | - | FC Juárez [U18] | 2:0 | ||||
| 3. Round | 17/07/2022 | UANL Tigres [U18] | - | Club Tijuana [U18] | 0:1 | ||||
| 4. Round | 23/07/2022 | Club Tijuana [U18] | - | CF América [U18] | 4:1 |  |
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| 5. Round | 26/07/2022 | Atlas Guadalajara [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 7. Round | 07/08/2022 | Deportivo Toluca [U18] | - | Club Tijuana [U18] | 2:1 | ||||
| 8. Round | 12/08/2022 | Club Tijuana [U18] | - | Puebla FC [U18] | 4:0 | ||||
| 9. Round | 17/08/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U18] | - | Deportivo Guadalajara [U18] | 1:0 | ||||
| 14. Round | 11/09/2022 | CF Pachuca [U18] | - | Club Tijuana [U18] | 4:2 | ||||
| 15. Round | 18/09/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 2:1 | ||||
| 17. Round | 02/10/2022 | Club León [U18] | - | Club Tijuana [U18] | 0:1 |
Mexico