| 2. Round | 15/01/2021 | Club Necaxa [U17] | - | Atlético San Luis [U17] | 5:2 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U17] | - | Deportivo Guadalajara [U17] | 0:3 | ||||
| 4. Round | 01/02/2021 | Club León [U17] | - | Atlético San Luis [U17] | 3:0 | ||||
| 5. Round | 04/02/2021 | Atlético San Luis [U17] | - | Club Tijuana [U17] | 1:1 | ||||
| 10. Round | 05/03/2021 | Atlético San Luis [U17] | - | Deportivo Toluca [U17] | 0:3 | ||||
| 11. Round | 14/03/2021 | Gallos Blancos [U17] | - | Atlético San Luis [U17] | 3:4 | ||||
| 12. Round | 20/03/2021 | Atlético San Luis [U17] | - | Pumas UNAM [U17] | 0:3 | ||||
| 13. Round | 03/04/2021 | CF Monterrey [U17] | - | Atlético San Luis [U17] | 4:1 | ||||
| 14. Round | 09/04/2021 | FC Juárez [U17] | - | Atlético San Luis [U17] | 2:0 | ||||
| 15. Round | 17/04/2021 | Atlético San Luis [U17] | - | Puebla FC [U17] | 2:1 |  |
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| 16. Round | 24/04/2021 | Cruz Azul [U17] | - | Atlético San Luis [U17] | 5:0 | ||||
| 17. Round | 29/04/2021 | Atlético San Luis [U17] | - | CF Pachuca [U17] | 1:2 |
Mexico