| 1. Round | 23/07/2022 | CSD Municipal | - | Cobán Imperial | 1:4 | ||||
| 2. Round | 30/07/2022 | Cobán Imperial | - | Deportivo Xinabajul | 3:1 | ||||
| 5. Round | 14/08/2022 | Cobán Imperial | - | Antigua GFC | 3:1 | ||||
| 6. Round | 21/08/2022 | Deportivo Malacateco | - | Cobán Imperial | 1:0 | ||||
| 9. Round | 03/09/2022 | Cobán Imperial | - | Deportivo Mixco | 0:0 | ||||
| 10. Round | 11/09/2022 | Xelaju MC | - | Cobán Imperial | 1:0 | ||||
| 14. Round | 09/10/2022 | Achuapa | - | Cobán Imperial | 2:2 | ||||
| 15. Round | 15/10/2022 | Cobán Imperial | - | Iztapa | 1:0 | ||||
| 18. Round | 06/11/2022 | Comunicaciones | - | Cobán Imperial | 2:2 | ||||
| 16. Round | 10/11/2022 | Antigua GFC | - | Cobán Imperial | 2:0 |
Guatemala