| 5. Round | 12/02/2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 0:1 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:1 | ||||
| 1. Round | 25/03/2022 | FC Juárez [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 13. Round | 07/04/2022 | Atlas Guadalajara [U20] | - | Club Necaxa [U20] | 1:1 |  |
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| 17. Round | 29/04/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 0:3 | |
Mexico