| 2. Round | 16/01/2022 | Leones Negros | - | Pumas Tabasco | 3:1 | ||||
| 3. Round | 20/01/2022 | Pumas Tabasco | - | TM Fútbol Club | 2:0 | ||||
| 7. Round | 09/02/2022 | Dorados de Sinaloa | - | Pumas Tabasco | 4:1 | ||||
| 11. Round | 10/03/2022 | Pumas Tabasco | - | Coyotes de Tlaxcala | 0:0 | ||||
| 12. Round | 17/03/2022 | Tepatitlán | - | Pumas Tabasco | 1:0 | ||||
| 15. Round | 31/03/2022 | Pumas Tabasco | - | Correcaminos UAT | 1:2 |  |
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| 16. Round | 05/04/2022 | Alebrijes de Oaxaca | - | Pumas Tabasco | 0:0 |
Mexico