| 8. Round | 13/08/2022 | Deportivo Guadalajara [U20] | - | Atlas Guadalajara [U20] | 1:1 | ||||
| 10. Round | 19/08/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 1:1 |  |
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| 11. Round | 27/08/2022 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 0:1 | ||||
| 12. Round | 04/09/2022 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 1:0 | ||||
| 13. Round | 07/09/2022 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 1:1 |  |
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| 14. Round | 10/09/2022 | Deportivo Guadalajara [U20] | - | Puebla FC [U20] | 1:1 | ||||
| 9. Round | 13/09/2022 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 1:0 | ||||
| 15. Round | 17/09/2022 | CF América [U20] | - | Deportivo Guadalajara [U20] | 2:2 |  |
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| 17. Round | 01/10/2022 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 1:1 | |
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Mexico