| 1. Round | 28/07/2020 | CF Pachuca | - | CF América | 1:2 | ||||
| 2. Round | 02/08/2020 | CF América | - | Club Tijuana | 4:0 | ||||
| 3. Round | 08/08/2020 | Club Necaxa | - | CF América | 1:1 |  |
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| 4. Round | 14/08/2020 | CF América | - | Santos Laguna | 3:1 | |
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| 5. Round | 17/08/2020 | Gallos Blancos | - | CF América | 4:1 | ||||
| 6. Round | 23/08/2020 | CF América | - | CF Monterrey | 1:3 | ||||
| 7. Round | 30/08/2020 | Atlético San Luis | - | CF América | 1:2 | ||||
| 8. Round | 03/09/2020 | CF América | - | Mazatlán FC | 3:1 | ||||
| 13. Round | 04/10/2020 | CF América | - | Pumas UNAM | 2:2 | ||||
| 14. Round | 20/10/2020 | Club León | - | CF América | 3:2 | |
Mexico