| 1. Round | 25/07/2021 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 2. Round | 01/08/2021 | Atlas Guadalajara | - | FC Juárez | 2:0 | ||||
| 3. Round | 10/08/2021 | CF Pachuca | - | Atlas Guadalajara | 0:1 | ||||
| 4. Round | 15/08/2021 | Atlas Guadalajara | - | CF América | 0:1 | ||||
| 5. Round | 19/08/2021 | Santos Laguna | - | Atlas Guadalajara | 1:1 | ||||
| 6. Round | 21/08/2021 | Atlas Guadalajara | - | Deportivo Toluca | 0:0 | ||||
| 7. Round | 29/08/2021 | UANL Tigres | - | Atlas Guadalajara | 1:1 |  |
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| 8. Round | 11/09/2021 | Atlas Guadalajara | - | CF Monterrey | 2:1 | ||||
| 9. Round | 18/09/2021 | Club Necaxa | - | Atlas Guadalajara | 0:3 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara | - | Club León | 2:0 | ||||
| 11. Round | 29/09/2021 | Atlas Guadalajara | - | Puebla FC | 0:1 | |
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| 12. Round | 03/10/2021 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:1 | ||||
| 13. Round | 16/10/2021 | Mazatlán FC | - | Atlas Guadalajara | 1:0 |  |
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| 15. Round | 25/10/2021 | Atlético San Luis | - | Atlas Guadalajara | 2:6 |  |
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| 16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Round | 05/11/2021 | Atlas Guadalajara | - | Gallos Blancos | 2:0 |
Mexico