| 1. Round | 01/07/2022 | Club Necaxa [U20] | - | Deportivo Toluca [U20] | 6:1 |  |
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| 3. Round | 17/07/2022 | Pumas UNAM [U20] | - | Club Necaxa [U20] | 1:2 |  |
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| 4. Round | 22/07/2022 | Club Necaxa [U20] | - | FC Juárez [U20] | 1:2 | |
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| 5. Round | 27/07/2022 | Club Necaxa [U20] | - | CF Pachuca [U20] | 0:1 | |
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| 6. Round | 30/07/2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 2:0 | ||||
| 8. Round | 12/08/2022 | Club Necaxa [U20] | - | CF Monterrey [U20] | 2:1 | ||||
| 10. Round | 19/08/2022 | Club Necaxa [U20] | - | Deportivo Guadalajara [U20] | 1:1 | ||||
| 12. Round | 02/09/2022 | Club Necaxa [U20] | - | Club León [U20] | 2:2 | ||||
| 13. Round | 06/09/2022 | Santos Laguna [U20] | - | Club Necaxa [U20] | 3:2 | |
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| 14. Round | 10/09/2022 | Club Necaxa [U20] | - | CF América [U20] | 1:2 | ||||
| 9. Round | 13/09/2022 | Puebla FC [U20] | - | Club Necaxa [U20] | 3:2 | ||||
| 15. Round | 18/09/2022 | Club Tijuana [U20] | - | Club Necaxa [U20] | 2:3 | ||||
| 11. Round | 21/09/2022 | UANL Tigres [U20] | - | Club Necaxa [U20] | 3:0 | |
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| 17. Round | 01/10/2022 | Atlas Guadalajara [U20] | - | Club Necaxa [U20] | 2:1 | |
Mexico