| 1. Round | 20/07/2001 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
| 3. Round | 03/08/2001 | Santos Laguna | - | Reboceros de la Piedad | 6:4 |  |
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| 6. Round | 17/08/2001 | Club León | - | Santos Laguna | 4:2 |  |
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| 8. Round | 06/09/2001 | Deportivo Toluca | - | Santos Laguna | 6:2 | |
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| 5. Round | 10/09/2001 | Santos Laguna | - | Pumas UNAM | 1:0 | ||||
| 9. Round | 14/09/2001 | Santos Laguna | - | CF Monterrey | 5:0 | ||||
| 10. Round | 21/09/2001 | Atletico Celaya | - | Santos Laguna | 1:3 | ||||
| 4. Round | 25/09/2001 | Cruz Azul | - | Santos Laguna | 0:0 | ||||
| 11. Round | 28/09/2001 | Santos Laguna | - | Deportivo Guadalajara | 0:1 | ||||
| 12. Round | 04/10/2001 | UAG Tecos | - | Santos Laguna | 1:2 | ||||
| 13. Round | 12/10/2001 | Puebla FC | - | Santos Laguna | 2:1 | ||||
| 14. Round | 18/10/2001 | Santos Laguna | - | Atlante | 2:1 |  |
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| 15. Round | 26/10/2001 | Monarcas Morelia | - | Santos Laguna | 3:2 | |
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| 16. Round | 02/11/2001 | Santos Laguna | - | CF América | 2:3 | ||||
| 17. Round | 09/11/2001 | CF Pachuca | - | Santos Laguna | 2:1 | ||||
| 18. Round | 16/11/2001 | Santos Laguna | - | UANL Tigres | 1:2 | ||||
| 19. Round | 23/11/2001 | Club Irapuato | - | Santos Laguna | 1:1 | |
Paraguay