| 1. Round | 04/01/2002 | Atlas Guadalajara | - | Santos Laguna | 3:3 | ||||
| 3. Round | 19/01/2002 | Reboceros de la Piedad | - | Santos Laguna | 1:0 | ||||
| 4. Round | 26/01/2002 | Santos Laguna | - | Cruz Azul | 2:2 | ||||
| 5. Round | 02/02/2002 | Pumas UNAM | - | Santos Laguna | 3:4 | ||||
| 6. Round | 09/02/2002 | Santos Laguna | - | Club León | 3:0 |  |
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| 7. Round | 16/02/2002 | Club Necaxa | - | Santos Laguna | 4:1 |  |
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| 8. Round | 23/02/2002 | Santos Laguna | - | Deportivo Toluca | 0:1 | |
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| 9. Round | 26/02/2002 | CF Monterrey | - | Santos Laguna | 2:3 | ||||
| 10. Round | 02/03/2002 | Santos Laguna | - | Atletico Celaya | 4:1 | |
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| 11. Round | 09/03/2002 | Deportivo Guadalajara | - | Santos Laguna | 0:0 | ||||
| 12. Round | 16/03/2002 | Santos Laguna | - | UAG Tecos | 3:2 | ||||
| 13. Round | 23/03/2002 | Santos Laguna | - | Puebla FC | 3:0 | ||||
| 14. Round | 29/03/2002 | Atlante | - | Santos Laguna | 2:1 | ||||
| 16. Round | 02/04/2002 | CF América | - | Santos Laguna | 2:2 | |
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| 15. Round | 06/04/2002 | Santos Laguna | - | Monarcas Morelia | 4:3 | ||||
| 17. Round | 13/04/2002 | Santos Laguna | - | CF Pachuca | 3:2 | ||||
| 18. Round | 19/04/2002 | UANL Tigres | - | Santos Laguna | 2:1 | |
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| 19. Round | 26/04/2002 | Santos Laguna | - | Veracruz (old) | 5:1 |
Paraguay