| 5. Round | 13/10/2021 | Correcaminos UAT II | - | Leones Negros II | 1:1 | ||||
| 6. Round | 16/10/2021 | Leones Negros II | - | Coras de Nayarit | 2:0 | ||||
| 7. Round | 23/10/2021 | Mineros de Fresnillo FC | - | Leones Negros II | 0:3 |  |
|||
| 8. Round | 30/10/2021 | Leones Negros II | - | Tuzos de la UAZ | 1:0 | ||||
| 9. Round | 06/11/2021 | Alacranes de Durango | - | Leones Negros II | 2:1 | ||||
| 10. Round | 10/11/2021 | Leones Negros II | - | Cimarrones de Sonora II | 1:2 |  |
|||
| 11. Round | 13/11/2021 | Saltillo FC | - | Leones Negros II | 3:1 | ||||
| 12. Round | 20/11/2021 | Leones Negros II | - | Tritones Vallarta | 3:3 | |
|||
| 13. Round | 27/11/2021 | Catedráticos Elite | - | Leones Negros II | 3:2 |
Mexico