| 1. Round | 18/09/2021 | Leones Negros II | - | Gavilanes de Matamoros | 2:2 | ||||
| 3. Round | 02/10/2021 | Mineros de Fresnillo FC | - | Gavilanes de Matamoros | 0:0 | ||||
| 5. Round | 14/10/2021 | Alacranes de Durango | - | Gavilanes de Matamoros | 1:0 | ||||
| 10. Round | 11/11/2021 | Gavilanes de Matamoros | - | Correcaminos UAT II | 2:0 | ||||
| 11. Round | 13/11/2021 | Gavilanes de Matamoros | - | Mazorqueros | 0:3 | ||||
| 12. Round | 20/11/2021 | Tecos Fútbol Club | - | Gavilanes de Matamoros | 2:0 |
Mexico