| 1. Round | 26/07/2010 | Real Mamoré | - | Blooming | 1:1 |  |
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| 2. Round | 01/08/2010 | Club San José | - | Blooming | 2:0 | ||||
| 3. Round | 08/08/2010 | Blooming | - | Universitario de Sucre | 2:1 | ||||
| 4. Round | 14/08/2010 | Blooming | - | La Paz FC | 2:0 | ||||
| 5. Round | 22/08/2010 | Jorge Wilstermann | - | Blooming | 0:1 | |
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| 6. Round | 29/08/2010 | Blooming | - | The Strongest | 2:1 | |
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| 7. Round | 05/09/2010 | CD Guabirá | - | Blooming | 0:0 | ||||
| 8. Round | 09/09/2010 | Blooming | - | Real Potosí | 2:2 | ||||
| 9. Round | 12/09/2010 | Oriente Petrolero | - | Blooming | 1:0 | ||||
| 10. Round | 19/09/2010 | Blooming | - | Club Aurora | 0:1 | ||||
| 11. Round | 26/09/2010 | Bolívar | - | Blooming | 1:0 |
Argentina