| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 | ||||
| 5. Round | 04/02/2021 | Atlético San Luis [U20] | - | Club Tijuana [U20] | 1:2 | ||||
| 6. Round | 12/02/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 1:0 | ||||
| 7. Round | 18/02/2021 | Atlético San Luis [U20] | - | Santos Laguna [U20] | 0:4 | ||||
| 8. Round | 25/02/2021 | Atlético San Luis [U20] | - | UANL Tigres [U20] | 2:1 | ||||
| 9. Round | 02/03/2021 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 2:0 | ||||
| 10. Round | 05/03/2021 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 1:2 | ||||
| 11. Round | 14/03/2021 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 16. Round | 24/04/2021 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 17. Round | 29/04/2021 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 2:0 |  |
Mexico