| 1. Round | 17/02/2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 |  |
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| 2. Round | 23/02/2022 | Rangers | - | Deportes Melipilla | 1:0 | ||||
| 3. Round | 02/03/2022 | Deportes Melipilla | - | Puerto Montt | 1:1 | ||||
| 4. Round | 11/03/2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 8. Round | 09/04/2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Round | 18/04/2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Round | 20/04/2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 |  |
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| 12. Round | 29/04/2022 | Deportes Melipilla | - | Barnechea | 2:1 | ||||
| 16. Round | 22/05/2022 | Deportes Melipilla | - | Santa Cruz | 1:0 |  |
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| 17. Round | 29/05/2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 19. Round | 12/07/2022 | Deportes Melipilla | - | Rangers | 1:2 | ||||
| 21. Round | 26/07/2022 | Deportes Melipilla | - | Recoleta | 1:2 | ||||
| 26. Round | 31/08/2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 34. Round | 01/11/2022 | Deportes Melipilla | - | Deportes Iquique | 0:0 |
Chile