| 2. Round | 13/03/2021 | Jorge Wilstermann | - | Nacional Potosí | 1:2 | ||||
| 1. Round | 28/03/2021 | Real Santa Cruz | - | Jorge Wilstermann | 0:2 | ||||
| 3. Round | 04/04/2021 | Oriente Petrolero | - | Jorge Wilstermann | 4:2 | ||||
| 4. Round | 11/04/2021 | Jorge Wilstermann | - | The Strongest | 0:3 | ||||
| 6. Round | 03/05/2021 | Atlético Palmaflor | - | Jorge Wilstermann | 3:1 |  |
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| 8. Round | 10/07/2021 | Royal Pari | - | Jorge Wilstermann | 3:2 | ||||
| 9. Round | 16/07/2021 | Jorge Wilstermann | - | Real Potosí | 3:1 | ||||
| 10. Round | 22/07/2021 | CD Guabirá | - | Jorge Wilstermann | 3:2 | ||||
| 14. Round | 08/08/2021 | Real Tomayapo | - | Jorge Wilstermann | 1:2 | |
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| 17. Round | 22/08/2021 | Nacional Potosí | - | Jorge Wilstermann | 0:1 | ||||
| 24. Round | 26/10/2021 | Real Potosí | - | Jorge Wilstermann | 2:2 |
Bolivia