| 1. Round | 08/01/2023 | Santos Laguna [U20] | - | UANL Tigres [U20] | 0:1 | ||||
| 2. Round | 14/01/2023 | Santos Laguna [U20] | - | Pumas UNAM [U20] | 1:6 | ||||
| 3. Round | 20/01/2023 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 2:3 | ||||
| 4. Round | 26/01/2023 | Atlas Guadalajara [U20] | - | Santos Laguna [U20] | 1:2 |  |
|||
| 5. Round | 04/02/2023 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 6. Round | 10/02/2023 | FC Juárez [U20] | - | Santos Laguna [U20] | 1:0 | ||||
| 9. Round | 26/02/2023 | Santos Laguna [U20] | - | Puebla FC [U20] | 4:3 | |
|||
| 12. Round | 19/03/2023 | Club León [U20] | - | Santos Laguna [U20] | 1:3 | ||||
| 13. Round | 31/03/2023 | Club Necaxa [U20] | - | Santos Laguna [U20] | 0:2 | ||||
| 14. Round | 09/04/2023 | Santos Laguna [U20] | - | CF Pachuca [U20] | 1:3 | ||||
| 15. Round | 16/04/2023 | CF Monterrey [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 7. Round | 19/04/2023 | Santos Laguna [U20] | - | Deportivo Toluca [U20] | 2:1 | ||||
| 16. Round | 23/04/2023 | Santos Laguna [U20] | - | Gallos Blancos [U20] | 4:1 | |
|||
| 17. Round | 29/04/2023 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 |
Mexico