| 1. Round | 11/01/2022 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 1:4 | ||||
| 2. Round | 18/01/2022 | UANL Tigres [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 4. Round | 28/01/2022 | Club Necaxa [Women] | - | Deportivo Guadalajara [Women] | 0:3 | ||||
| 13. Round | 29/03/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:2 | ||||
| 9. Round | 11/04/2022 | Deportivo Guadalajara [Women] | - | FC Juárez [Women] | 0:0 |
Mexico