5. Round | 11/09/2021 | CD Santa Clara | - | SL Benfica | 0:5 | ||||
7. Round | 26/09/2021 | CD Santa Clara | - | Sporting Braga | 1:1 | ||||
8. Round | 02/10/2021 | FC Vizela | - | CD Santa Clara | 1:1 | ||||
10. Round | 31/10/2021 | Belenenses SAD | - | CD Santa Clara | 2:1 | ||||
11. Round | 07/11/2021 | CD Santa Clara | - | FC Porto | 0:3 | ||||
12. Round | 29/11/2021 | GD Estoril | - | CD Santa Clara | 2:2 | ||||
16. Round | 30/12/2021 | Paços de Ferreira | - | CD Santa Clara | 2:1 | ||||
18. Round | 16/01/2022 | CD Santa Clara | - | CD Tondela | 2:2 |