| 1. Round | 08/08/2020 | FC Nitra | - | Slovan Bratislava | 0:5 | ||||
| 2. Round | 11/08/2020 | MŠK Žilina | - | FC Nitra | 1:2 | ||||
| 3. Round | 15/08/2020 | FC DAC 1904 | - | FC Nitra | 6:0 | ||||
| 4. Round | 22/08/2020 | FC Nitra | - | MFK Ružomberok | 1:1 | ||||
| 5. Round | 29/08/2020 | FK Senica | - | FC Nitra | 0:0 | ||||
| 6. Round | 12/09/2020 | FC Nitra | - | FK Pohronie | 3:1 |  |
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| 7. Round | 19/09/2020 | AS Trenčín | - | FC Nitra | 3:2 | ||||
| 8. Round | 26/09/2020 | FC Nitra | - | ŠKF Sereď | 3:0 | ||||
| 9. Round | 03/10/2020 | Spartak Trnava | - | FC Nitra | 0:2 | ||||
| 12. Round | 01/11/2020 | Slovan Bratislava | - | FC Nitra | 0:1 | ||||
| 13. Round | 08/11/2020 | FC Nitra | - | MŠK Žilina | 0:3 | ||||
| 14. Round | 21/11/2020 | FC Nitra | - | FC DAC 1904 | 0:1 | ||||
| 15. Round | 28/11/2020 | MFK Ružomberok | - | FC Nitra | 3:0 | ||||
| 16. Round | 05/12/2020 | FC Nitra | - | FK Senica | 1:1 | ||||
| 17. Round | 06/02/2021 | FK Pohronie | - | FC Nitra | 3:1 | ||||
| 20. Round | 20/02/2021 | FC Nitra | - | Spartak Trnava | 0:1 | ||||
| 19. Round | 23/02/2021 | ŠKF Sereď | - | FC Nitra | 1:2 | ||||
| 21. Round | 27/02/2021 | FC Nitra | - | Zlaté Moravce | 0:1 | ||||
| 22. Round | 06/03/2021 | MFK Zemplín Michalovce | - | FC Nitra | 1:0 |
Slovakia