| 4. Round | 12/08/2017 | MŠK Žilina | - | FK Senica | 7:1 | ||||
| 6. Round | 25/08/2017 | MŠK Žilina | - | Spartak Trnava | 3:1 |  |
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| 7. Round | 09/09/2017 | FK Železiarne Podbrezová | - | MŠK Žilina | 2:4 | ||||
| 8. Round | 16/09/2017 | MŠK Žilina | - | AS Trenčín | 5:1 | |
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| 9. Round | 19/09/2017 | MFK Ružomberok | - | MŠK Žilina | 1:0 | ||||
| 10. Round | 24/09/2017 | MŠK Žilina | - | Slovan Bratislava | 3:2 | |
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| 11. Round | 30/09/2017 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | ||||
| 12. Round | 15/10/2017 | MŠK Žilina | - | FC Nitra | 2:0 | ||||
| 13. Round | 22/10/2017 | 1. FC Tatran Prešov | - | MŠK Žilina | 0:1 | ||||
| 14. Round | 28/10/2017 | MŠK Žilina | - | Zlaté Moravce | 2:0 | ||||
| 15. Round | 05/11/2017 | FK Senica | - | MŠK Žilina | 4:1 | ||||
| 16. Round | 18/11/2017 | MŠK Žilina | - | FC DAC 1904 | 0:0 | ||||
| 17. Round | 25/11/2017 | Spartak Trnava | - | MŠK Žilina | 0:3 | |
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| 20. Round | 18/02/2018 | MŠK Žilina | - | MFK Ružomberok | 2:0 | ||||
| 21. Round | 24/02/2018 | Slovan Bratislava | - | MŠK Žilina | 6:0 | ||||
| 22. Round | 03/03/2018 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 |
Slovakia