| 2. Round | 19/05/2022 | Portland Thorns [Women] | - | Washington Spirit [Women] | 1:1 |  |
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| 2. Round | 22/05/2022 | OL Reign [Women] | - | Washington Spirit [Women] | 0:0 | ||||
| 2. Round | 28/05/2022 | Orlando Pride [Women] | - | Washington Spirit [Women] | 2:2 | ||||
| 3. Round | 02/06/2022 | Washington Spirit [Women] | - | Chicago Red Stars [Women] | 1:1 | ||||
| 3. Round | 05/06/2022 | NJ/NY Gotham FC [Women] | - | Washington Spirit [Women] | 1:0 | ||||
| 3. Round | 09/06/2022 | Chicago Red Stars [Women] | - | Washington Spirit [Women] | 0:0 | ||||
| 3. Round | 12/06/2022 | Washington Spirit [Women] | - | NC Courage [Women] | 2:3 | ||||
| 3. Round | 18/06/2022 | Washington Spirit [Women] | - | Racing Louisville [Women] | 2:2 |  |
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| 4. Round | 03/07/2022 | San Diego Wave FC [Women] | - | Washington Spirit [Women] | 2:1 | ||||
| 6. Round | 18/09/2022 | Washington Spirit [Women] | - | NJ/NY Gotham FC [Women] | 2:0 |
USA