| 1. Round | 24/07/2021 | FK Khimki | - | Zenit St. Petersburg | 1:3 |  |
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| 15. Round | 19/11/2021 | Zenit St. Petersburg | - | FK Nizhny Novgorod | 5:1 | ||||
| 16. Round | 28/11/2021 | CSKA Moskva | - | Zenit St. Petersburg | 0:2 | ||||
| 18. Round | 12/12/2021 | Dinamo Moskva | - | Zenit St. Petersburg | 1:1 | ||||
| 19. Round | 28/02/2022 | Zenit St. Petersburg | - | Rubin Kazan | 3:2 | ||||
| 22. Round | 19/03/2022 | Zenit St. Petersburg | - | Arsenal Tula | 3:0 | ||||
| 24. Round | 09/04/2022 | Akhmat Grozny | - | Zenit St. Petersburg | 0:2 | ||||
| 25. Round | 16/04/2022 | Zenit St. Petersburg | - | FK Ural | 3:1 | ||||
| 26. Round | 25/04/2022 | FK Krasnodar | - | Zenit St. Petersburg | 1:3 |  |
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| 27. Round | 30/04/2022 | Zenit St. Petersburg | - | Lokomotiv Moskva | 3:1 | ||||
| 28. Round | 07/05/2022 | Zenit St. Petersburg | - | FK Khimki | 1:0 | ||||
| 29. Round | 15/05/2022 | Spartak Moskva | - | Zenit St. Petersburg | 1:1 | ||||
| 30. Round | 21/05/2022 | FK Nizhny Novgorod | - | Zenit St. Petersburg | 1:0 | |
Russia