| 3. Round | 16/06/2021 | Central Español | - | CA Cerro | 3:2 | ||||
| 4. Round | 26/06/2021 | Defensor Sporting | - | Central Español | 4:0 | ||||
| 5. Round | 30/06/2021 | Albion | - | Central Español | 1:2 | ||||
| 6. Round | 07/07/2021 | Central Español | - | Atenas | 0:3 |  |
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| 7. Round | 15/07/2021 | Racing | - | Central Español | 1:0 | ||||
| 9. Round | 29/07/2021 | Juventud de Las Piedras | - | Central Español | 1:1 | ||||
| 10. Round | 05/08/2021 | Central Español | - | Uruguay Montevideo | 1:3 |  |
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| 15. Round | 05/10/2021 | Central Español | - | Defensor Sporting | 1:0 | ||||
| 16. Round | 11/10/2021 | Central Español | - | Albion | 3:4 | ||||
| 19. Round | 02/11/2021 | Villa Teresa | - | Central Español | 1:2 | ||||
| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 | |
Uruguay