| 5. Round | 10/07/2010 | Toronto FC | - | Colorado Rapids | 1:0 | ||||
| 5. Round | 17/07/2010 | Philadelphia Union | - | Toronto FC | 2:1 | ||||
| 5. Round | 24/07/2010 | Toronto FC | - | FC Dallas | 1:1 |  |
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| 6. Round | 01/08/2010 | Kansas City Wizards | - | Toronto FC | 1:0 | ||||
| 6. Round | 07/08/2010 | Toronto FC | - | CD Chivas | 2:1 | ||||
| 7. Round | 09/09/2010 | Chicago Fire | - | Toronto FC | 0:0 | ||||
| 7. Round | 11/09/2010 | Toronto FC | - | D.C. United | 0:1 | ||||
| 7. Round | 19/09/2010 | Houston Dynamo | - | Toronto FC | 1:2 |  |
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| 7. Round | 25/09/2010 | Toronto FC | - | San Jose Earthquakes | 2:3 | |
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| 8. Round | 02/10/2010 | Seattle Sounders | - | Toronto FC | 3:2 | |
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| 8. Round | 10/10/2010 | CD Chivas | - | Toronto FC | 3:0 | ||||
| 8. Round | 16/10/2010 | Toronto FC | - | Columbus Crew | 2:2 | |
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| 8. Round | 24/10/2010 | D.C. United | - | Toronto FC | 2:3 | |
Brazil