| 8. Round | 19/09/2021 | FK Nizhny Novgorod | - | Arsenal Tula | 2:3 | ||||
| 9. Round | 27/09/2021 | FK Ural | - | Arsenal Tula | 2:0 |  |
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| 10. Round | 02/10/2021 | Arsenal Tula | - | FK Khimki | 0:0 | ||||
| 11. Round | 16/10/2021 | Arsenal Tula | - | Zenit St. Petersburg | 2:1 | ||||
| 15. Round | 21/11/2021 | Dinamo Moskva | - | Arsenal Tula | 5:1 | ||||
| 17. Round | 05/12/2021 | FK Khimki | - | Arsenal Tula | 1:2 | ||||
| 18. Round | 11/12/2021 | CSKA Moskva | - | Arsenal Tula | 2:0 | |
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| 19. Round | 26/02/2022 | FK Sochi | - | Arsenal Tula | 2:0 | |
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| 20. Round | 06/03/2022 | Krylia Sovetov | - | Arsenal Tula | 2:2 | ||||
| 22. Round | 19/03/2022 | Zenit St. Petersburg | - | Arsenal Tula | 3:0 | ||||
| 25. Round | 17/04/2022 | Arsenal Tula | - | FK Rostov | 1:2 | |
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| 27. Round | 02/05/2022 | Arsenal Tula | - | FK Nizhny Novgorod | 2:2 |
Russia