| 1. Round | 13/03/2010 | Krylia Sovetov | - | Zenit St. Petersburg | 0:1 | ||||
| 3. Round | 27/03/2010 | Dinamo Moskva | - | Zenit St. Petersburg | 1:2 | ||||
| 4. Round | 28/04/2010 | CSKA Moskva | - | Zenit St. Petersburg | 0:2 | ||||
| 9. Round | 06/05/2010 | Zenit St. Petersburg | - | Spartak Nalchik | 3:1 | ||||
| 10. Round | 10/05/2010 | FK Amkar Perm | - | Zenit St. Petersburg | 0:2 |  |
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| 11. Round | 04/07/2010 | Zenit St. Petersburg | - | Anzhi Makhachkala | 2:1 | ||||
| 14. Round | 24/07/2010 | FK Rostov | - | Zenit St. Petersburg | 1:3 | ||||
| 15. Round | 31/07/2010 | Zenit St. Petersburg | - | Rubin Kazan | 2:0 | ||||
| 24. Round | 16/10/2010 | Zenit St. Petersburg | - | FK Amkar Perm | 2:0 | ||||
| 25. Round | 24/10/2010 | Anzhi Makhachkala | - | Zenit St. Petersburg | 3:3 | ||||
| 29. Round | 20/11/2010 | Rubin Kazan | - | Zenit St. Petersburg | 2:2 | ||||
| 30. Round | 28/11/2010 | Zenit St. Petersburg | - | Krylia Sovetov | 0:0 |
Russia