| 1. Round | 25/07/2021 | Desna Chernigov | - | Chernomorets Odessa | 3:0 | ||||
| 2. Round | 31/07/2021 | Chernomorets Odessa | - | SK Dnipro-1 | 0:3 | ||||
| 3. Round | 06/08/2021 | Metalist 1925 Kharkiv | - | Chernomorets Odessa | 3:2 | ||||
| 4. Round | 16/08/2021 | FK Mariupol | - | Chernomorets Odessa | 2:3 | ||||
| 5. Round | 21/08/2021 | Chernomorets Odessa | - | Shakhtar Donetsk | 0:3 | ||||
| 6. Round | 27/08/2021 | Chernomorets Odessa | - | FK Oleksandriya | 2:2 |  |
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| 7. Round | 12/09/2021 | FC Mynai | - | Chernomorets Odessa | 2:2 | ||||
| 8. Round | 19/09/2021 | Zorya Lugansk | - | Chernomorets Odessa | 3:0 | ||||
| 9. Round | 27/09/2021 | Chernomorets Odessa | - | Inhulets Petrove | 1:1 | ||||
| 10. Round | 02/10/2021 | Kolos Kovalivka | - | Chernomorets Odessa | 2:1 | |
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| 13. Round | 01/11/2021 | Vorskla Poltava | - | Chernomorets Odessa | 0:0 | |
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| 15. Round | 19/11/2021 | Chernomorets Odessa | - | Dinamo Kiev | 1:6 | ||||
| 17. Round | 06/12/2021 | SK Dnipro-1 | - | Chernomorets Odessa | 3:1 | ||||
| 18. Round | 12/12/2021 | Chernomorets Odessa | - | Metalist 1925 Kharkiv | 2:1 |
Ukraine