| 2. Round | 11/08/2020 | Slovan Bratislava | - | MFK Zemplín Michalovce | 5:0 | ||||
| 3. Round | 15/08/2020 | FK Senica | - | MFK Zemplín Michalovce | 3:0 |  |
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| 7. Round | 19/09/2020 | MFK Ružomberok | - | MFK Zemplín Michalovce | 4:0 | ||||
| 8. Round | 26/09/2020 | MFK Zemplín Michalovce | - | FK Pohronie | 2:0 | ||||
| 12. Round | 31/10/2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 |
Ukraine