| 1. Round | 24/07/2021 | Shakhtar Donetsk | - | Inhulets Petrove | 2:1 | ||||
| 2. Round | 02/08/2021 | Inhulets Petrove | - | Zorya Lugansk | 1:5 | ||||
| 3. Round | 09/08/2021 | Desna Chernigov | - | Inhulets Petrove | 2:0 | ||||
| 4. Round | 18/08/2021 | Inhulets Petrove | - | Dinamo Kiev | 1:1 | ||||
| 5. Round | 23/08/2021 | FK Lviv | - | Inhulets Petrove | 1:2 | ||||
| 6. Round | 28/08/2021 | Inhulets Petrove | - | FK Mariupol | 3:0 | ||||
| 7. Round | 10/09/2021 | FK Oleksandriya | - | Inhulets Petrove | 1:0 | ||||
| 8. Round | 18/09/2021 | Inhulets Petrove | - | Kolos Kovalivka | 0:2 | ||||
| 9. Round | 27/09/2021 | Chernomorets Odessa | - | Inhulets Petrove | 1:1 |  |
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| 10. Round | 02/10/2021 | Vorskla Poltava | - | Inhulets Petrove | 3:0 | ||||
| 12. Round | 22/10/2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 | ||||
| 13. Round | 30/10/2021 | Inhulets Petrove | - | NK Veres | 0:0 | ||||
| 14. Round | 07/11/2021 | Inhulets Petrove | - | SK Dnipro-1 | 0:1 | |
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| 15. Round | 21/11/2021 | FC Mynai | - | Inhulets Petrove | 2:2 |  |
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| 16. Round | 28/11/2021 | Inhulets Petrove | - | Shakhtar Donetsk | 0:1 |
Ukraine