| 1. Round | 25/07/2021 | Zorya Lugansk | - | FK Oleksandriya | 0:1 | ||||
| 2. Round | 02/08/2021 | Inhulets Petrove | - | Zorya Lugansk | 1:5 | ||||
| 5. Round | 22/08/2021 | FK Mariupol | - | Zorya Lugansk | 3:4 |  |
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| 8. Round | 19/09/2021 | Zorya Lugansk | - | Chernomorets Odessa | 3:0 | ||||
| 9. Round | 26/09/2021 | SK Dnipro-1 | - | Zorya Lugansk | 0:4 | ||||
| 10. Round | 03/10/2021 | Zorya Lugansk | - | Desna Chernigov | 2:0 | ||||
| 11. Round | 15/10/2021 | Shakhtar Donetsk | - | Zorya Lugansk | 6:1 | ||||
| 12. Round | 24/10/2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 14. Round | 07/11/2021 | Zorya Lugansk | - | NK Veres | 3:0 | ||||
| 15. Round | 20/11/2021 | FK Lviv | - | Zorya Lugansk | 2:1 |  |
Ukraine