| 1. Round | 05/05/2021 | Barcelona [Women] | - | LDJ [Women] | 2:1 | ||||
| 2. Round | 13/05/2021 | Deportivo Cuenca [Women] | - | Barcelona [Women] | 4:1 |  |
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| 3. Round | 17/05/2021 | Barcelona [Women] | - | Técnico Universitario [Women] | 2:0 | ||||
| 4. Round | 22/05/2021 | Barcelona [Women] | - | Guayaquil City [Women] | 5:0 | ||||
| 5. Round | 29/05/2021 | Macará [Women] | - | Barcelona [Women] | 0:0 | ||||
| 7. Round | 12/06/2021 | Emelec [Women] | - | Barcelona [Women] | 0:0 | ||||
| 8. Round | 19/06/2021 | LDJ [Women] | - | Barcelona [Women] | 1:1 | ||||
| 9. Round | 26/06/2021 | Barcelona [Women] | - | Deportivo Cuenca [Women] | 0:0 | ||||
| 6. Round | 30/06/2021 | Barcelona [Women] | - | UPS Carneras [Women] | 2:0 | ||||
| 10. Round | 03/07/2021 | Técnico Universitario [Women] | - | Barcelona [Women] | 0:2 | ||||
| 13. Round | 25/07/2021 | UPS Carneras [Women] | - | Barcelona [Women] | 1:0 | ||||
| 14. Round | 01/08/2021 | Barcelona [Women] | - | Emelec [Women] | 3:0 |
Venezuela