| 1. Round | 30/08/1997 | Skoda Xanthi | - | OFI Heraklion | 2:1 | ||||
| 3. Round | 20/09/1997 | AO Proodeftiki | - | OFI Heraklion | 2:2 | ||||
| 4. Round | 27/09/1997 | OFI Heraklion | - | Olympiakos Piraeus | 2:3 | ||||
| 5. Round | 04/10/1997 | AO Kavala | - | OFI Heraklion | 3:3 | ||||
| 6. Round | 18/10/1997 | OFI Heraklion | - | Iraklis Saloniki | 1:0 | ||||
| 7. Round | 25/10/1997 | Ionikos Nikea | - | OFI Heraklion | 5:0 |  |
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| 8. Round | 01/11/1997 | OFI Heraklion | - | Panathinaikos | 0:3 | |
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| 9. Round | 08/11/1997 | OFI Heraklion | - | Paniliakos Pyrgos | 3:2 |  |
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| 11. Round | 22/11/1997 | OFI Heraklion | - | Apollon Smyrnis | 2:1 | ||||
| 12. Round | 29/11/1997 | Panachaiki GE | - | OFI Heraklion | 0:2 | ||||
| 13. Round | 06/12/1997 | OFI Heraklion | - | Veria FC | 3:0 | ||||
| 14. Round | 13/12/1997 | Ethnikos Piraeus | - | OFI Heraklion | 0:1 | ||||
| 17. Round | 10/01/1998 | PS Kalamata | - | OFI Heraklion | 1:0 | ||||
| 18. Round | 17/01/1998 | OFI Heraklion | - | Skoda Xanthi | 2:1 | ||||
| 19. Round | 24/01/1998 | PAOK Saloniki | - | OFI Heraklion | 1:0 | ||||
| 25. Round | 07/03/1998 | Panathinaikos | - | OFI Heraklion | 6:2 | |
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| 31. Round | 02/05/1998 | OFI Heraklion | - | Ethnikos Piraeus | 3:0 | |
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| 34. Round | 16/05/1998 | OFI Heraklion | - | PS Kalamata | 1:0 |
Greece