| 1. Round | 12/09/2020 | OFI Heraklion | - | Panetolikos | 1:1 | ||||
| 2. Round | 19/09/2020 | Panetolikos | - | AEK Athen | 0:2 | ||||
| 3. Round | 26/09/2020 | Olympiakos Piraeus | - | Panetolikos | 2:0 | ||||
| 4. Round | 03/10/2020 | Panetolikos | - | Asteras Tripolis | 1:1 | ||||
| 5. Round | 19/10/2020 | Lamia | - | Panetolikos | 0:0 | ||||
| 9. Round | 22/11/2020 | Panetolikos | - | Aris Saloniki | 0:1 |  |
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| 10. Round | 29/11/2020 | Panathinaikos | - | Panetolikos | 2:1 | ||||
| 11. Round | 07/12/2020 | Panetolikos | - | AE Lárissa | 2:1 | ||||
| 12. Round | 13/12/2020 | Volos NFC | - | Panetolikos | 0:0 |  |
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| 14. Round | 03/01/2021 | Panetolikos | - | OFI Heraklion | 2:1 | ||||
| 15. Round | 06/01/2021 | AEK Athen | - | Panetolikos | 1:0 | ||||
| 17. Round | 16/01/2021 | Asteras Tripolis | - | Panetolikos | 2:0 | ||||
| 19. Round | 28/01/2021 | Panetolikos | - | Atromitos | 1:1 | ||||
| 20. Round | 31/01/2021 | PAOK Saloniki | - | Panetolikos | 5:0 | ||||
| 21. Round | 08/02/2021 | Panetolikos | - | PAS Giannina | 1:2 | ||||
| 23. Round | 22/02/2021 | Panetolikos | - | Panathinaikos | 1:0 |
Greece