| 17. Round | 23/01/2022 | Excelsior Virton | - | Waasland-Beveren | 0:4 | ||||
| 18. Round | 30/01/2022 | Waasland-Beveren | - | KVC Westerlo | 2:1 | ||||
| 19. Round | 05/02/2022 | Royal Excel Mouscron | - | Waasland-Beveren | 3:0 | ||||
| 20. Round | 11/02/2022 | Waasland-Beveren | - | Lierse Kempenzonen | 0:1 | ||||
| 21. Round | 19/02/2022 | Waasland-Beveren | - | RWD Molenbeek | 1:0 | ||||
| 22. Round | 25/02/2022 | KVC Westerlo | - | Waasland-Beveren | 2:1 | ||||
| 24. Round | 13/03/2022 | KMSK Deinze | - | Waasland-Beveren | 3:3 |
France
Portugal