| 3. Round | 10/08/2008 | Puebla FC | - | Santos Laguna | 0:0 |  |
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| 5. Round | 24/08/2008 | Puebla FC | - | Monarcas Morelia | 2:0 | ||||
| 6. Round | 28/08/2008 | CF Pachuca | - | Puebla FC | 2:0 | |
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| 8. Round | 14/09/2008 | Atlas Guadalajara | - | Puebla FC | 2:0 | ||||
| 9. Round | 21/09/2008 | Puebla FC | - | UANL Tigres | 0:0 | |
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| 10. Round | 27/09/2008 | Club San Luis | - | Puebla FC | 1:1 | |
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| 12. Round | 12/10/2008 | CF América | - | Puebla FC | 1:1 |
Mexico