| 2. Round | 21/01/2021 | TM Fútbol Club | - | Leones Negros | 0:0 | ||||
| 3. Round | 31/01/2021 | Tepatitlán | - | TM Fútbol Club | 1:0 | ||||
| 4. Round | 04/02/2021 | TM Fútbol Club | - | Cancún FC | 1:1 | ||||
| 5. Round | 10/02/2021 | TM Fútbol Club | - | Coyotes de Tlaxcala | 1:0 | ||||
| 6. Round | 19/02/2021 | Tapatío | - | TM Fútbol Club | 1:0 | ||||
| 7. Round | 24/02/2021 | TM Fútbol Club | - | Mineros de Zacatecas | 4:0 | ||||
| 11. Round | 25/03/2021 | TM Fútbol Club | - | Cimarrones de Sonora | 0:1 | ||||
| 12. Round | 28/03/2021 | Correcaminos UAT | - | TM Fútbol Club | 2:2 | ||||
| 13. Round | 01/04/2021 | TM Fútbol Club | - | Atlante | 0:0 | ||||
| 14. Round | 07/04/2021 | Alebrijes de Oaxaca | - | TM Fútbol Club | 4:1 | ||||
| 15. Round | 14/04/2021 | TM Fútbol Club | - | Dorados de Sinaloa | 0:0 |
USA