| 4. Round | 12/08/2018 | Deportivo Guadalajara [U20] | - | Santos Laguna [U20] | 3:0 | ||||
| 5. Round | 19/08/2018 | Santos Laguna [U20] | - | UANL Tigres [U20] | 3:3 | ||||
| 6. Round | 22/08/2018 | Club Tijuana [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 7. Round | 27/08/2018 | Santos Laguna [U20] | - | Cruz Azul [U20] | 2:0 | ||||
| 8. Round | 02/09/2018 | Deportivo Toluca [U20] | - | Santos Laguna [U20] | 3:2 | ||||
| 16. Round | 11/11/2018 | Santos Laguna [U20] | - | CF América [U20] | 0:0 |
USA