1. Round | 04/02/2022 | Club Olimpia | - | General Caballero DJLM | 2:2 | ||||
2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
4. Round | 25/02/2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
15. Round | 10/05/2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 | ||||
17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
19. Round | 17/06/2022 | General Caballero DJLM | - | Sol de América | 1:1 | ||||
20. Round | 21/06/2022 | Cerro Porteño | - | General Caballero DJLM | 3:1 |