| 27. Round | 25/08/2024 | Portland Timbers | - | St. Louis City SC | 4:4 |  |
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| 28. Round | 01/09/2024 | St. Louis City SC | - | Los Angeles Galaxy | 2:1 |  |
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| 29. Round | 08/09/2024 | New England Revolution | - | St. Louis City SC | 2:2 | ||||
| 29. Round | 15/09/2024 | St. Louis City SC | - | Minnesota United FC | 1:3 | ||||
| 31. Round | 22/09/2024 | San Jose Earthquakes | - | St. Louis City SC | 1:2 | |
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| 32. Round | 29/09/2024 | St. Louis City SC | - | Sporting Kansas City | 3:1 | ||||
| 33. Round | 03/10/2024 | Los Angeles FC | - | St. Louis City SC | 1:0 | |
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| 34. Round | 06/10/2024 | St. Louis City SC | - | Houston Dynamo | 3:0 | ||||
| 35. Round | 20/10/2024 | Minnesota United FC | - | St. Louis City SC | 4:1 | |
Germany