| 1. Round | 26/07/2021 | Club Tijuana | - | UANL Tigres | 1:2 | ||||
| 2. Round | 31/07/2021 | Club León | - | Club Tijuana | 2:1 | ||||
| 6. Round | 22/08/2021 | CF América | - | Club Tijuana | 2:0 | ||||
| 8. Round | 11/09/2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
| 9. Round | 17/09/2021 | Atlético San Luis | - | Club Tijuana | 4:1 | ||||
| 12. Round | 04/10/2021 | Club Tijuana | - | Cruz Azul | 0:1 | ||||
| 15. Round | 24/10/2021 | Pumas UNAM | - | Club Tijuana | 3:1 | ||||
| 16. Round | 29/10/2021 | Atlas Guadalajara | - | Club Tijuana | 0:2 | ||||
| 17. Round | 07/11/2021 | Club Tijuana | - | CF Pachuca | 3:2 |  |
Mexico