4. Round | 26/02/2022 | Guaraní | - | Resistencia SC | 3:3 | ||||
15. Round | 12/05/2022 | Resistencia SC | - | Guaraní | 1:2 | ||||
16. Round | 17/05/2022 | Guaraní | - | 12 de Octubre de Itauguá | 3:0 | ||||
17. Round | 22/05/2022 | General Caballero DJLM | - | Guaraní | 0:4 | ||||
18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 | ||||
20. Round | 23/06/2022 | Guaraní | - | Sportivo Ameliano | 1:1 | ||||
21. Round | 26/06/2022 | Club Nacional | - | Guaraní | 0:1 | ||||
22. Round | 03/07/2022 | Guaraní | - | Club Olimpia | 0:2 |