| 1. Round | 06/02/2021 | 12 de Octubre de Itauguá | - | River Plate | 2:2 | ||||
| 3. Round | 15/02/2021 | Sol de América | - | River Plate | 1:1 | ||||
| 4. Round | 19/02/2021 | River Plate | - | Sportivo Luqueño | 1:0 |  |
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| 5. Round | 01/03/2021 | Libertad | - | River Plate | 2:1 | ||||
| 6. Round | 05/03/2021 | River Plate | - | Guaireña FC | 0:1 | ||||
| 7. Round | 09/03/2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Round | 13/03/2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 10. Round | 01/04/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 |  |
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| 12. Round | 18/04/2021 | River Plate | - | Sol de América | 0:2 | ||||
| 13. Round | 26/04/2021 | Sportivo Luqueño | - | River Plate | 2:2 | ||||
| 14. Round | 04/05/2021 | River Plate | - | Libertad | 1:3 | |
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| 15. Round | 10/05/2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Round | 16/05/2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
| 17. Round | 24/05/2021 | Club Nacional | - | River Plate | 0:1 | ||||
| 18. Round | 30/05/2021 | River Plate | - | Club Olimpia | 1:2 |
Paraguay