| 1. Round | 17/01/2010 | Puebla FC | - | UANL Tigres | 0:1 | ||||
| 2. Round | 23/01/2010 | Estudiantes Tecos | - | Puebla FC | 2:3 |  |
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| 3. Round | 31/01/2010 | Puebla FC | - | Gallos Blancos (old) | 1:2 | ||||
| 4. Round | 07/02/2010 | Atlante | - | Puebla FC | 1:1 | ||||
| 5. Round | 14/02/2010 | Puebla FC | - | CF Pachuca | 3:5 | |
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| 6. Round | 18/02/2010 | Puebla FC | - | Club San Luis | 1:0 |  |
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| 7. Round | 21/02/2010 | Deportivo Guadalajara | - | Puebla FC | 3:2 | |
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| 9. Round | 07/03/2010 | Pumas UNAM | - | Puebla FC | 4:1 | ||||
| 12. Round | 29/03/2010 | Puebla FC | - | CF América | 2:1 | |
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| 13. Round | 04/04/2010 | Monarcas Morelia | - | Puebla FC | 1:1 | ||||
| 14. Round | 11/04/2010 | Puebla FC | - | Indios Juárez | 1:2 | ||||
| 16. Round | 18/04/2010 | Puebla FC | - | Cruz Azul | 4:1 |
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