| 1. Round | 03/02/2017 | Libertad | - | Guaraní | 3:2 |  |
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| 2. Round | 11/02/2017 | Guaraní | - | Sol de América | 2:1 | |
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| 3. Round | 17/02/2017 | General Díaz | - | Guaraní | 1:2 | |
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| 4. Round | 26/02/2017 | Guaraní | - | Club Olimpia | 3:3 | |
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| 6. Round | 11/03/2017 | Guaraní | - | Independiente CG | 3:2 | |
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| 5. Round | 15/03/2017 | Sportivo Luqueño | - | Guaraní | 0:1 | ||||
| 7. Round | 19/03/2017 | Sportivo Trinidense | - | Guaraní | 1:2 | |
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| 8. Round | 27/03/2017 | Deportivo Capiatá | - | Guaraní | 1:0 | ||||
| 10. Round | 02/04/2017 | Club Rubio Ñu | - | Guaraní | 1:2 | ||||
| 11. Round | 09/04/2017 | Guaraní | - | Club Nacional | 1:3 | |
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| 14. Round | 01/05/2017 | Guaraní | - | General Díaz | 0:0 |  |
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| 9. Round | 17/05/2017 | Guaraní | - | Cerro Porteño | 2:1 | ||||
| 18. Round | 29/05/2017 | Guaraní | - | Sportivo Trinidense | 4:1 | ||||
| 20. Round | 11/06/2017 | Cerro Porteño | - | Guaraní | 0:4 | ||||
| 21. Round | 18/06/2017 | Guaraní | - | Club Rubio Ñu | 2:1 | |
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| 22. Round | 24/06/2017 | Club Nacional | - | Guaraní | 1:2 | |
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